Ke hoʻolauna nei iā PQQ: ʻO ka Ultimate Energy Booster no ka noʻonoʻo a me ke kino

Ke hoʻolauna nei iā PQQ: ʻO ka Ultimate Energy Booster no ka noʻonoʻo a me ke kino

ʻO Pyrroloquinoline quinone, i kapa ʻia ʻo PQQ, he hui prosthetic hou me nā hana physiological like me nā huaora. Loaʻa ia i loko o nā prokaryotes, nā mea kanu a me nā mammals, e like me ka soybeans fermented a i ʻole natto, nā pepa ʻōmaʻomaʻo, nā hua kiwi, Parsley, ti, papaya, spinach, celery, waiū umauma, etc.

I nā makahiki i hala iho nei, ua lilo ʻo PQQ i hoʻokahi o nā meaʻai "hōkū" i huki nui ʻia. Ma 2022 a me 2023, ua ʻae koʻu ʻāina i ka PQQ i hana ʻia e ka synthesis a me ka fermentation ma ke ʻano he meaʻai hou.

ʻO nā hana koʻikoʻi o PQQ ka mea nui ma nā ʻano ʻelua. ʻO ka mea mua, hiki iā ia ke kākoʻo i ka uluʻana a me ka uluʻana o ka mitochondria a hoʻoulu i ka ulu wikiwiki o nā pūnaewele kanaka; ʻO ka lua, loaʻa iā ia nā waiwai antioxidant maikaʻi, hiki ke kōkua i ka wehe ʻana i nā radical manuahi a hoʻemi i ka pōʻino cell. ʻO kēia mau hana ʻelua he hana ikaika ia i ke olakino lolo, olakino cardiovascular, olakino metabolic a me nā mea ʻē aʻe. No ka mea ʻaʻole hiki i ke kino o ke kanaka ke synthesize PQQ iā ia iho, pono e hoʻohui ʻia ma o nā meaʻai meaʻai.

01.PQQ ka hana i ka hoʻomaikaʻi ʻana i ka cognition

I Pepeluali 2023, ua paʻi nā mea noiʻi Kepani i kahi pepa noiʻi i kapa ʻia ʻo "Pyrroloquinoline quinone disodium salt e hoʻomaikaʻi i ka hana o ka lolo i nā ʻōpio a me nā poʻe ʻelemakule" ma ka puke "Food & Function", e hoʻolauna ana i ka ʻike o ka PQQ i nā ʻōpio a me nā poʻe kahiko ma Iapana. Ua hoʻomaikaʻi ʻia nā hopena noiʻi.

ʻO kēia haʻawina he ʻelua makapō placebo randomized controlled trial i komo pū me 62 mau kāne Kepani olakino i piha i ka makahiki 20-65, me nā helu Mini-Mental State Scale ≥ 24, nāna i mālama i ko lākou nohona kumu i ka wā aʻo. Huina wahine. Ua hoʻokaʻawale ʻia nā kumuhana noiʻi i loko o kahi pūʻulu hana a me kahi hui hoʻomalu placebo, a hāʻawi waha ʻia ʻo PQQ (20 mg / d) a i ʻole nā ​​​​kāpena placebo i kēlā me kēia lā no 12 pule. Ua hoʻohana ʻia kahi ʻōnaehana hoʻāʻo pūnaewele i kūkulu ʻia e kahi hui no ka ʻike ʻana i nā pule 0/8/12. Hoʻoholo ka hoʻāʻo cognitive i nā hana o ka lolo he 15.

Ua hōʻike nā hopena i ka hoʻohālikelike ʻia me ka hui hoʻomalu placebo, ma hope o 12 mau pule o ka lawe ʻana i ka PQQ, ua hoʻonui ʻia ka hoʻomanaʻo composite a me nā helu hoʻomanaʻo waha o nā hui āpau a me ka hui ʻelemakule; ma hope o 8 mau pule o ka lawe ʻana i ka PQQ, ua hoʻonui ʻia ka maʻalahi o ka naʻau o ka hui ʻōpio, ka wikiwiki o ka hana ʻana a me ka hoʻokō.

02 ʻAʻole hiki i ka PQQ ke hoʻomaikaʻi wale i ka hana o ka lolo o ka poʻe ʻelemakule, akā hoʻomaikaʻi pū i ka pane o ka lolo o ka poʻe ʻōpio!

Ma Malaki 2023, ua paʻi ka puke pai honua kaulana ʻo Food & Function i kahi pepa noiʻi i kapa ʻia ʻo "Pyrroloquinoline quinone disodium salt e hoʻomaikaʻi i ka hana o ka lolo i nā ʻōpio a me nā ʻelemakule". Ua noiʻi kēia noiʻi i ka hopena o ka PQQ i ka hana cognitive o nā pākeke makahiki 20-65, e hoʻonui ana i ka heluna kanaka noiʻi o PQQ mai ka poʻe ʻelemakule a hiki i ka poʻe ʻōpio. Ua hōʻoia ka haʻawina e hiki i ka PQQ ke hoʻomaikaʻi i ka hana cognitive o nā poʻe o nā makahiki āpau.

Ua ʻike ka noiʻi ʻo PQQ, ma ke ʻano he meaʻai hana, hiki ke hoʻomaikaʻi i ka hana o ka lolo i kēlā me kēia makahiki, a manaʻo ʻia e hoʻonui i ka hoʻohana ʻana i ka PQQ ma ke ʻano he meaʻai hana mai ka poʻe ʻelemakule a hiki i nā poʻe o nā makahiki āpau.

Hana ʻo 03 PQQ ma ke ʻano he mea hoʻoikaika o "nā hale hana ikehu cell" e hoʻihoʻi i ko lākou olakino

I Mei 2023, ua hoʻopuka ʻo Cell Death Dis i kahi pepa noiʻi i kapa ʻia ʻo Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cell. Ua ʻike ʻia kēia haʻawina i ka PQQ ma ka nānā ʻana inā pilikia ka mana o ka mea hāʻawi i ka mitochondrial intercellular o nā mea momona (ka poʻe me nā maʻi metabolic) a me ka hopena therapeutic o nā mesenchymal stem cell (MSCs), a inā paha e hiki ke hoʻohuli i ka lāʻau mitochondrial-targeted therapy. Hoʻihoʻi ka modulation i ke olakino mitochondrial e hoʻēmi i ka mitophagy impaired.
Hāʻawi kēia haʻawina i ka ʻike mua loa o ka molecular impaired impaired impaired impaired impaired mesenchymal stem cell a hōʻike e hiki ke hoʻihoʻi ʻia ke olakino mitochondrial ma o ka hoʻoponopono PQQ e hoʻēmi i ka mitophagy impaired.

04 PQQ hiki ke hoʻomaikaʻi i ka hana metabolic kanaka

I Mei 2023, ua paʻi ʻia kahi ʻatikala loiloi i kapa ʻia ʻo "Pyrroloquinoline-quinone e hōʻemi i ka hōʻiliʻili momona a hoʻomaikaʻi i ka holomua o ka momona" i paʻi ʻia ma ka puke pai Front Mol Biosci, nāna i hōʻuluʻulu i nā haʻawina holoholona 5 a me nā haʻawina cell 2.
Hōʻike nā hopena i hiki i ka PQQ ke hōʻemi i ka momona o ke kino, ʻoi aku ka nui o ka momona visceral a me ka ate, a laila e pale ai i ka momona o ka meaʻai. Mai kahi loiloi kumu, PQQ ka mea nui e kāohi i ka lipogenesis a hōʻemi i ka hōʻiliʻili momona ma o ka hoʻomaikaʻi ʻana i ka hana mitochondrial a me ka hoʻoulu ʻana i ka lipid metabolism.

Hiki i ka 05 PQQ ke pale i ka osteoporosis ma muli o ka ʻelemakule maoli

I Kepakemapa 2023, ua paʻi ʻo Aging Cell i kahi pepa noiʻi i kapa ʻia ʻo "Pyrroloquinoline quinone e hōʻoluʻolu i ka osteoporosis pili i ka ʻelemakule ma o ka moʻolelo MCM3-Keap1-Nrf2 axis-mediated stress pane a me Fbn1 upregulation" ma ka pūnaewele. ʻO ke aʻo ʻana, ma o nā hoʻokolohua ma nā ʻiole, ua ʻike ʻia e hiki i nā mea hoʻohui PQQ meaʻai ke pale i ka osteoporosis ma muli o ka ʻelemakule maoli. Hāʻawi ke kumu kumu o ka mana antioxidant ikaika o PQQ i kumu hoʻokolohua no ka hoʻohana ʻana o PQQ ma ke ʻano he meaʻai meaʻai no ka pale ʻana i ka osteoporosis pili i ka makahiki.
Hōʻike kēia haʻawina i ka hana kūpono a me ka hana hou o ka PQQ i ka pale ʻana a me ka mālama ʻana i ka osteoporosis senile, a hōʻoia ʻia hiki ke hoʻohana ʻia ka PQQ ma ke ʻano he meaʻai palekana a maikaʻi hoʻi e pale a mālama i ka osteoporosis senile. I ka manawa like, ua hōʻike ʻia ʻo PQQ e hoʻāla i ka hōʻailona MCM3-Keap1-Nrf2 i nā osteoblasts, transcriptionally upregulates ka hōʻike ʻana o nā genes antioxidant a me Fbn1 genes, inhibits stress oxidative a me osteoclast bone resorption, a hoʻoikaika i ka hoʻokumu ʻana o ka iwi osteoblast, a laila e pale ai i ka ʻelemakule. kuleana i ka hiki ʻana o ka osteoporosis sexual.

06 Hiki i ka hoʻonui ʻana i ka PQQ ke pale aku i nā ʻāpana ganglion retinal a hoʻomaikaʻi i ke olakino maka!

I Kepakemapa 2023, ua paʻi ka puke pai Acta Neuropathol Commun i kahi noiʻi mai nā loea ophthalmology kūpono a me nā loea mai ka Halemai Maka o Karolinska Institutet ma Stockholm, Suedena, kahi kula lapaʻau kaulana ʻEulopa, a me ka Royal Victoria Eye and Ear Hospital ma Australia, a me ke Keʻena Biology o ke Kulanui o Pisa ma Italia. Ua kapa ʻia ʻo "Pyrroloquinoline quinone drives ATP synthesis in vitro a in vivo a hāʻawi i ka retinal ganglion cell neuroprotection." Ua hōʻoia ka noiʻi ʻana he hopena pale ka PQQ i nā pūnaewele ganglion retinal (RGC) a loaʻa iā ia ka mana nui ma ke ʻano he mea neuroprotective hou i ke kūʻē ʻana i ka retinal ganglion cell apoptosis.
Kākoʻo nā ʻike i ke kuleana kūpono o ka PQQ ma ke ʻano he mea neuroprotective ʻike maka hou e hiki ke hoʻomaikaʻi i ke kūpaʻa ʻana o nā cell ganglion retinal ʻoiai e hōʻemi ana i ka hopena o nā hopena ʻaoʻao. I ka manawa like, manaʻo ka poʻe noiʻi ʻo ka hoʻohui ʻana i ka PQQ he koho kūpono no ka mālama ʻana i ke olakino maka.

07 Hiki i ka hoʻonui ʻana i ka PQQ ke hoʻoponopono i nā pua ʻōpū, hoʻomaikaʻi i ka hana thyroid, a hōʻemi i ka pōʻino thyroid.

I Kekemapa 2023, ua paʻi kahi hui noiʻi mai ka Halemai ʻo Shanghai Tenth People's Hospital of Tongji University School of Medicine i kahi ʻatikala i kapa ʻia ʻo "The Potential Role of Pyrroloquinoline Quinone to Regulate Thyroid Function and Gut Microbiota Composition of Graves' Disease in Mice" i loko o ka puke pai Pol J Microbiol Ma kēia ʻatikala, ua hoʻohana nā mea noiʻi i ke kumu hoʻohālike PQtest e hōʻike i nā mea noiʻi e hoʻohui i ka PQtest florate a pau pōʻino o ka ʻōpū, a hoʻomaikaʻi i ka hana thyroid.
Ua ʻike ʻia ka haʻawina i nā hopena o ka hoʻohui PQQ i nā ʻiole GD a me kā lākou ʻōpū ʻōpū:

01 Ma hope o ka PQQ supplementation, ua ho'ēmiʻia ka TSHR a me T4 o nāʻiole GD, a ua hoʻemi nuiʻia ka nui o ka thyroid gland.

02 PQQ ho'ēmi i ka mumū a me ka oxidative koʻikoʻi, a ho'ēmi i ka poino epithelial'ōpū liʻiliʻi.

03 He hopena koʻikoʻi ka PQQ i ka hoʻihoʻi ʻana i ka ʻokoʻa a me ka hoʻohui ʻana o ka microbiota.

04 Hoʻohālikelike ʻia me ka pūʻulu GD, hiki i ka lāʻau PQQ ke hōʻemi i ka nui o Lactobacilli i nā ʻiole (ʻo ia ka hopena i hoʻopaʻa ʻia no ke kaʻina GD).

I ka hōʻuluʻuluʻana, hiki i ka PQQ supplementation ke hoʻoponopono i ka hana thyroid, hoʻemi i ka pōʻino thyroid, a hoʻemi i ka mumū a me ke kaumaha oxidative, a laila e hoʻohaʻahaʻa i ka pōʻino epithelial intestinal liʻiliʻi. A hiki i ka PQQ ke hoʻihoʻi hou i ka ʻokoʻa o nā pua ʻōpū.

Ma waho aʻe o nā haʻawina i luna e hōʻike ana i ke kuleana koʻikoʻi a me ka palena ʻole o ka PQQ ma ke ʻano he meaʻai meaʻai e hoʻomaikaʻi ai i ke olakino kanaka, ua hoʻomau ʻia nā haʻawina mua e hōʻoia i nā hana ikaika o PQQ.

08 Hiki i ka PQQ ke hoʻomaikaʻi i ka hypertension pulmonary

I ʻOkakopa 2022, ua paʻi ʻia kahi pepa noiʻi i kapa ʻia ʻo "Pyrroloquinoline quinone (PQQ) e hoʻomaikaʻi i ka hypertension pulmonary ma o ka hoʻoponopono ʻana i nā hana mitochondrial a me ka metabolic" i paʻi ʻia ma ka puke pai Pulmonary Pharmacology & Therapeutics, e ʻimi ana e ʻimi i ka hana a PQQ i ka hoʻomaikaʻi ʻana i ka hypertension pulmonary.
Hōʻike nā hualoaʻa e hiki i ka PQQ ke hoʻohaʻahaʻa i nā meaʻinoʻole o ka mitochondrial a me nā meaʻinoʻino i loko o nā puʻupuʻu puʻupuʻu māmā a hoʻopaneʻe i ka piʻiʻana o ka hypertension pulmonary i nāʻiole; no laila, hiki ke hoʻohana ʻia ka PQQ ma ke ʻano he lāʻau lapaʻau kūpono e hoʻomaikaʻi ai i ka hypertension pulmonary.

09 Hiki i ka PQQ ke hoʻolōʻihi i ka ʻelemakule a hoʻonui i ke ola!

I Ianuali 2020, kahi pepa noiʻi i kapa ʻia ʻo Pyrroloquinoline quinone e hoʻopaneʻe i ka inflammaging i hoʻoulu ʻia e TNF-α ma o nā ala hōʻailona p16/p21 a me Jagged1 i paʻi ʻia ma Clin Exp Pharmacol Physiol i hōʻoia pololei i ka hopena anti-aging o PQQ i loko o nā cell kanaka. , Hōʻike nā hualoaʻa e hoʻopaneʻe ka PQQ i ka ʻelemakule o ke kanaka a hiki ke hoʻonui i ke ola.

Ua ʻike nā mea noiʻi hiki i ka PQQ ke hoʻopaneʻe i ka ʻelemakule o ke kanaka, a hōʻoia hou i kēia hopena ma o nā hopena hōʻike o nā biomarkers he nui e like me p21, p16, a me Jagged1. Manaʻo ʻia e hiki i ka PQQ ke hoʻomaikaʻi i ke olakino holoʻokoʻa o ka heluna kanaka a hoʻonui i ke ola.

Hiki i ka 10 PQQ ke pale i ka ʻelemakule ovarian a mālama i ka momona

Ma Malaki 2022, ua paʻi ʻia kahi pepa noiʻi i kapa ʻia ʻo "PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice" i loko o ka puke pai Front Endocrinol, me ka manaʻo e aʻo inā pale nā ​​meaʻai meaʻai PQQ mai ka alkylating agent-induced ovarian dysfunction. hopena.
Ua hōʻike nā hopena i ka hoʻonui ʻana o ka PQQ supplementation i ke kaumaha a me ka nui o nā ovaries, hoʻihoʻi hapa i ka pōʻino estrous pōʻino, a pale i ka nalowale ʻana o nā follicles i nā ʻiole i mālama ʻia me nā mea hana alkylating. Eia kekahi, hoʻonui nui ka PQQ supplementation i ka nui o ka hāpai ʻana a me ka nui o ka litter no ka hāʻawi ʻana i nā ʻiole i mālama ʻia e ka alkylating agent. Hōʻike kēia mau hopena i ka hiki ke komo i ka PQQ supplementation i ka alkylating agent-induced ovarian dysfunction.

Ka hopena
ʻOiaʻiʻo, ma ke ʻano he meaʻai hou, ua ʻike ʻia ʻo PQQ no kāna mau hopena maikaʻi i ka meaʻai a me ke olakino. Ma muli o kāna mau hana ikaika, palekana kiʻekiʻe a me ke kūpaʻa maikaʻi, loaʻa iā ia nā manaʻo hoʻomohala ākea ma ke kahua o nā meaʻai hana.
I nā makahiki i hala iho nei, me ka hoʻonui ʻana i ka ʻike, ua loaʻa i ka PQQ ka palapala hōʻoia efficacy piha loa a hoʻohana nui ʻia ma ke ʻano he meaʻai meaʻai a meaʻai paha ma ʻAmelika Hui Pū ʻIa, ʻEulopa a me nā ʻāina a me nā ʻāina ʻē aʻe. Ke hoʻomau nei ka ʻike o ka poʻe kūʻai kūloko, manaʻo ʻia ʻo PQQ, ma ke ʻano he meaʻai hou, e hana i kahi honua hou i ka mākeke kūloko.

Kuhikuhi:

1.TAMAKOSHI M, SUZUKI T, NISHIHARA E, et al. ʻO ka paʻakai Pyrroloquinoline quinone disodium e hoʻomaikaʻi i ka hana o ka lolo i nā ʻōpio a me nā ʻelemakule [J]. Meaʻai & Hana, 2023, 14 (5): 2496-501.doi: 10.1039/d2fo01515c.2. Masanori Tamakoshi, Tomomi Suzuki, Eiichiro Nishihara, et al. Pyrroloquinoline quinone disodium paʻakai hoʻomaikaʻi i ka hana o ka lolo ma nā ʻōpio a me nā ʻelemakule. Hana Hana ʻAi ʻAi Hoʻāʻo Hoʻokolo like ʻole. 2023 Mar 6;14(5):2496-2501. PMID: 36807425.3. Shakti Sagar, Md Imam Faizan, Nisha Chaudhary, et al. Hoʻopilikia ka momona i ka cardiolipin-dependent mitophagy a me ka therapeutic intercellular mitochondrial hiki ke hoʻololi i nā pūnaewele mesenchymal stem. Make Cell Dis. 2023 Mei 13;14(5):324. doi: 10.1038/s41419-023-05810-3. PMID: 37173333.4. Nur Syafiqah Mohamad Ishak , Kazuto Ikemoto. ʻO Pyrroloquinoline-quinone e hōʻemi i ka hōʻiliʻili momona a hoʻomaikaʻi i ka holomua o ka momona. FrontMolBiosci.2023Mei5:10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi Xue, et al. Hoʻopau ka Pyrroloquinoline quinone i ka osteoporosis pili i ka ʻelemakule ma o ka moʻolelo MCM3-Keap1-Nrf2 axis-mediated stress pane a me ka Fbn1 upregulation. Kelepona kahiko. 2023 Sep;22(9):e13912. doi: 10.1111/acel.13912. Epupa 2023 Iune 26. PMID: 37365714.6. ʻO Alessio Canovai, James R Tribble, Melissa Jöe. et. al. ʻO ka Pyrroloquinoline quinone ke alakaʻi i ka ATP synthesis in vitro a in vivo a hāʻawi i ka retinal ganglion cell neuroprotection. Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. PMID: 37684640.7. Xiaoyan Liu , Wen Jiang , Ganghua Lu , et al. ʻO ke kuleana kūpono o Pyrroloquinoline Quinone e hoʻoponopono i ka hana Thyroid a me Gut Microbiota Composition o Graves' Disease in Mice. Pol J Microbiol. 2023 Dec 16;72(4):443-460. doi: 10.33073/pjm-2023-042. eCollection 2023 Dec 1. PMID: 38095308.8. Shafiq, Mohammad et al. "Hoʻomaikaʻi ʻo Pyrroloquinoline quinone (PQQ) i ka hypertension pulmonary ma o ka hoʻoponopono ʻana i nā hana mitochondrial a me ka metabolic." Pulmonary pharmacology & therapeutics vol. 76 (2022): 102156. doi:10.1016/j.pupt.2022.1021569. ʻO Ying Gao, Teru Kamogashira, Chisato Fujimoto. et al. Hoʻopaneʻe ka Pyrroloquinoline quinone i ka inflammaging i hoʻoulu ʻia e TNF-α ma o nā ala hōʻailona p16/p21 a me Jagged1. ʻO Clin Exp Pharmacol Physiol. 2020 Ian;47(1):102-110. doi: 10.1111/1440-1681.13176. PMID: 31520547.10.Dai, Xiuliang et al. ʻO ka PQQ Dietary Supplementation ke pale aku i ka Alkylating Agent-Induced Ovarian Dysfunction i nā ʻiole. Nā palena i ka endocrinology vol. 13 781404. 7 Mar. 2022, doi:10.3389/fendo.2022.781404